Ceruloplasmin/Hephaestin Knockout Mice Model Morphologic and Molecular Features of AMD

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.

PURPOSE Iron is an essential element in human metabolism but also is a potent generator of oxidative damage with levels that increase with age. Several studies suggest that iron accumulation may be a factor in age-related macular degeneration (AMD). In prior studies, both iron overload and features of AMD were identified in mice deficient in the ferroxidase ceruloplasmin (Cp) and its homologue ...

Classification and Clinical Features of AMD

Tetranectin knockout mice develop features of Parkinson disease.

BACKGROUND/AIMS Aggregation of insoluble α-synuclein to form Lewy bodies (LBs) may contribute to the selective loss of midbrain dopaminergic neurons in Parkinson disease (PD). Lack of robust animal models has impeded elucidation of the molecular mechanisms of LB formation and other critical aspects of PD pathogenesis. METHODS We established a mouse model with targeted deletion of the plasmino...

Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice.

Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the efferent ductules and rete testis were primary targets of estrogen receptor function. In the present study, a more comprehensive evaluation of the ERKO male reproductive tract was performed to determin...

Testability Features of the AMD-K6 Microprocessor